Primary Ovarian Insufficiency

By L. Nelson. New England Journal of Medicine, 2009

920 citations recorded by the source corpus.

A 30-year-old woman presents with a history of no menses since she stopped taking oral contraceptives 6 months ago in order to conceive. She had undergone puberty that was normal in both timing and development, with menarche at 12 years of age. At 18 years of age, she started taking oral contraceptives for irregular menses. She reports stress at work. Her weight is 59 kg, and her height 1.66 m; her body-mass index (the weight in kilograms divided by the square of the height in meters) is 21.3. There is no galactorrhea, hirsutism, or acne. The pelvic examination is normal, a pregnancy test is negative, the prolactin level is normal, and the follicle-stimulating hormone (FSH) level is in the menopausal range. How should she be evaluated and treated?

Subfields: Molecular Biology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/c3b64091870bf960bc04ced87e24459fc739b5a5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Matzuk
2. D. Ehrmann

In Reproductive Medicine

1. Ankur K. Nagaraja
2. M. Matzuk
3. M. Edson
4. D. Ehrmann
5. R. Legro
6. Bart C. J. M. Fauser

Citations in the corpus

• Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. (2015, background): “POI Loss of ovarian function before the age of 40 y with waxing and waning course and potential resumption of menses, conception, and pregnancy (320).”
• The mammalian ovary from genesis to revelation. (2009, background): “and testing for autoimmune disorders (including adrenal and thyroid) (213), additional genetic tests may become”
• Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment (2013, methodology): “For the ovary, LATS1-null female mice exhibited a POI phenotype (24), whereas LATS1 regulates the transcriptional activity of FOXL2, a gene mutated in some POI patients (25) (Fig.”
• Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline (2013, background): “Primary ovarian insufficiency Amenorrhea combined with symptoms of estrogen deficiency including hot flashes and urogenital symptoms Serum FSH (elevated), serum estradiol (low) Nelson, 2009 (296)”