Functional-Anatomic Fractionation of the Brain's Default Network

By Jessica R. Andrews-Hanna, Jay S. Reidler, Jorge Sepulcre, Renee M. Poulin, Randy L. Buckner. Neuron, 2010

2,667 citations recorded by the source corpus.

Summary One of the most consistent observations in human functional imaging is that a network of brain regions referred to as the “default network” increases its activity during passive states. Here we explored the anatomy and function of the default network across three studies to resolve divergent hypotheses about its contributions to spontaneous thought and active forms of decision-making. Analysis of intrinsic activity revealed the network comprises multiple, dissociated components. A midline core (posterior cingulate and anterior medial prefrontal cortex) is active when people make self-relevant, affective decisions. In contrast, a medial temporal lobe subsystem becomes engaged when decisions involve constructing a mental scene based on memory. During certain experimentally-directed and spontaneous acts of future-oriented thought, these dissociated components are simultaneously engaged presumably to facilitate construction of mental models of personally-significant events.

Subfields: Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/c375d491c539ffb0e9a08dd0a4d5d75385a502dc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

Citations in the corpus

Network attributes for segregation and integration in the human brain. (2013, background): “Employing a similar clustering approach to functional connectivity patterns of the default mode network suggested that the network can be subdivided into structural components and intrinsic circuits that are associated with different mental processes [29].”
CONTROL OF SLEEP AND WAKEFULNESS (2012, neutral): “Anatomically, the default network consists of regions along the anterior and posterior midline, the lateral parietal cortex, prefrontal cortex, and temporal lobe (33, 1040).”
The cingulate cortex and limbic systems for emotion, action, and memory (2019, background): “1, account for why it is activated in the resting state and is included as part of the ‘default-mode’ network (Andrews-Hanna et al. 2010; Leech and Sharp 2014).”
Default network activity, coupled with the frontoparietal control network, supports goal-directed cognition (2010, positive): “The neurocognitive function of the default network is not well characterized; yet the network is reliably engaged during spontaneous internal mentation (Andrews-Hanna et al., 2010), including selfreferential (D'Argembeau et al.”
Investigating the Phenomenological Matrix of Mindfulness-related Practices from a Neurocognitive Perspective (2015, background): “In the Attention Network Test (ANT, Fan, McCandliss, Sommer, Raz, & Posner, 2002), for example, the orienting subsystem of attention is characterized by faster target detection reaction times for those targets appearing at locations at which attention was directed prior to the target onset versus ta”