Recent advances in 3D printing of biomaterials

By Helena N. Chia, Benjamin M. Wu. Journal of Biological Engineering, 2015

1,533 citations recorded by the source corpus.

3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D Printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagnostic platforms, and drug delivery systems. Fueled by the recent explosion in public interest and access to affordable printers, there is renewed interest to combine stem cells with custom 3D scaffolds for personalized regenerative medicine. Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. In this review, the major materials and technology advances within the last five years for each of the common 3D Printing technologies (Three Dimensional Printing, Fused Deposition Modeling, Selective Laser Sintering, Stereolithography, and 3D Plotting/Direct-Write/Bioprinting) are described. Examples are highlighted to illustrate progress of each technology in tissue engineering, and key limitations are identified to motivate future research and advance this fascinating field of advanced manufacturing.

Subfields: Automotive Engineering, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/c3469ac1064a4045c1bb519a1247bb60c464ab8c

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In Biomedical Engineering

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Citations in the corpus

• PCL and PCL-based materials in biomedical applications (2018, background): “However, processing and fabricating complex shapes of these materials with a number of fabrication techniques such as solid free form fabrication (SFF) technologies are limited due to low stiffness and low stability which may result in collapse of the fabricated structures [149].”
• Effective design and simulation of surface-based lattice structures featuring volume fraction and cell type grading (2018, background): “In each of these areas, the scope to use lattices to provide highly tailored properties is extensive, not least because AM processes enable their production in materials ranging from biocompatible polymers [12,13] to high strength metal alloys [14,15].”
• Advantages and disadvantages of 3-dimensional printing in surgery: A systematic review. (2016, background): “Bioprinting represents a huge step forward in tissue engineering and is likely to enable the repair of anatomic defects and the reconstruction of complex organs in the foreseeable future.(5) In the present review, we focus on nonbiologic printing techniques for which the data are most extensive curr”