Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease

By Jean C. Augustinack, A. Schneider, E. Mandelkow, Bradley T. Hyman. Acta Neuropathologica, 2014

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Tau protein liquid–liquid phase separation can initiate tau aggregation (2018, neutral): “However, hyperphosphorylation of tau often coexists with tau aggregation in the diseased brain (Augustinack et al , 2002; Iqbal et al , 2005), but the data for a causal relationship of tau aggregation to tau phosphorylation are conflicting (Kumar et al , 2014; Tepper et al , 2014; (cid:1) Simi (cid”
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms (2018, background): “Tau hyperphosphorylation has been associated with the memory decline observed in Alzheimer’s disease patients (Augustinack et al., 2002; Huang and Jiang, 2009), possibly indicating a mechanism underlying memory impairment following ketamine use (see Memory and cognitive impairment section).”