Novel mechanisms and devices to enable successful transdermal drug delivery.

By B. W. Barry. European Journal of Pharmaceutical Sciences, 2001

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Dermal and Transdermal Drug Delivery Systems: Current and Future Prospects (2006, background): “$2 billion (Barry 2001) and this figure represents 10% of the overall U.”
Ultrasonic drug delivery – a general review (2004, background): “Therapeutic levels of ultrasound (1 – 3 MHz, 1 – 3 W/cm2) have been used for years to drive small hydrophobic molecules, such as steroids, into or through the skin [91,92,96-101].”
Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum (2015, background): “The limited permeability of molecules is due to the outermost layer of the skin, the stratum corneum [38,39].”
Influence of cholesterol on liposome stability and on in vitro drug release (2015, background): “Liposomes have been extensively investigated for drug targeting [4] [5], drug delivery [6] [7], controlled release [8], and increased solubility [9].”