45Obesity, Insulin Resistance and Free Fatty Acids
By G. Boden. Current Opinion in Endocrinology, Diabetes & Obesity, 2011
771 citations recorded by the source corpus.
Purpose of reviewTo describe the role of free fatty acid (FFA) as a cause for insulin resistance in obese people. Recent findingsElevated plasma FFA levels can account for a large part of insulin resistance in obese patients with type 2 diabetes. Insulin resistance is clinically important because it is closely associated with several diseases including type 2 diabetes, hypertension, dyslipidemia and abnormalities in blood coagulation and fibrinolysis. These disorders are all independent risk factors for cardiovascular disease (heart attacks, strokes and peripheral arterial disease). The mechanisms by which FFA can cause insulin resistance, although not completely known, include generation of lipid metabolites (diacylglycerol), proinflammatory cytokines (TNF-α, IL-1β, IL-6, MCP1) and cellular stress including oxidative and endoplasmic reticulum stress. SummaryIncreased plasma FFA levels are an important cause of obesity-associated insulin resistance and cardiovascular disease. Therapeutic application of this knowledge is hampered by the lack of readily accessible methods to measure FFA and by the lack of medications to lower plasma FFA levels.
Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/c2ca5a43019bc3b60f6c7c762ab3b5c2d4b2badd
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In Endocrinology, Diabetes and Metabolism
In Epidemiology
In Nutrition and Dietetics
Citations in the corpus
- Metabolic syndrome update. (2016, background): “A mediator between adipose-tissue fat and ectopic fat appears to be a high plasma level of non-esterified fatty acids (NEFA) [19].”
- Dyslipidemia in Obesity: Mechanisms and Potential Targets (2013, background): “Other reviews have been published recently by several other groups as well [3,84].”