The role of MicroRNAs in human cancer
By Yong Peng, Carlo Maria Croce. Signal Transduction and Targeted Therapy, 2016
2,271 citations recorded by the source corpus.
MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that function in regulation of gene expression. Compelling evidences have demonstrated that miRNA expression is dysregulated in human cancer through various mechanisms, including amplification or deletion of miRNA genes, abnormal transcriptional control of miRNAs, dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. MiRNAs may function as either oncogenes or tumor suppressors under certain conditions. The dysregulated miRNAs have been shown to affect the hallmarks of cancer, including sustaining proliferative signaling, evading growth suppressors, resisting cell death, activating invasion and metastasis, and inducing angiogenesis. An increasing number of studies have identified miRNAs as potential biomarkers for human cancer diagnosis, prognosis and therapeutic targets or tools, which needs further investigation and validation. In this review, we focus on how miRNAs regulate the development of human tumors by acting as tumor suppressors or oncogenes.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c25f12c2106cb0ed9fe3dec82ca5d76026610ad6
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In Cancer Research
In Molecular Biology
Citations in the corpus
- MIENTURNET: an interactive web tool for microRNA-target enrichment and network-based analysis (2019, background): “Nowadays, it is becoming more and more evident that miRNAs are playing significant roles in regulatory mechanisms operating in various organisms, including developmental timing, cell differentiation, proliferation, apoptosis as well as tumorigenesis [4, 5].”