Harnessing the power of an X-ray laser for serial crystallography of membrane proteins crystallized in lipidic cubic phase

By Ming-Yue Lee, J. Geiger, A. Ishchenko, G. Han, A. Barty, T. White, C. Gati, A. Batyuk, M. Hunter, A. Aquila and 4 more. 2020

14 citations recorded by the source corpus.

Serial femtosecond crystallography of adenosine A2A receptor (A2AAR) crystallized in lipidic cubic phase was performed using high X-ray free-electron laser transmission with a high dynamic range detector in a helium atmosphere. The 2.0 Å resolution A2AAR structure model is presented and compared with previous A2AAR structures determined in a vacuum and/or at cryogenic temperatures.

Subfields: Materials Chemistry, Molecular Biology, Structural Biology

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In Materials Chemistry

1. Anima Anandkumar
2. Weili Nie
3. Arash Vahdat
4. Thomas F. Miller
5. Zhuoran Qiao

In Molecular Biology

1. Anima Anandkumar
2. Weili Nie
3. Arash Vahdat
4. Thomas F. Miller
5. Zhuoran Qiao

Citations in the corpus

• State-specific protein–ligand complex structure prediction with a multiscale deep generative model (2022, positive): “Figure 5g shows representative predicted structures for a G-protein-coupled receptor (GPCR), human adenosine receptor A2a (PDB:6WQA), on which the predicted antagonist-bound structure agrees well with the experimental structure 51 with a TM-score = 0.86.”