Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor

By A. Quintana, E. Raczka, L. Piehler, Inhan Lee, A. Myc, I. Majoros, A. Patri, Thommey P. Thomas, J. Mulé, J. Baker. Pharmaceutical Research, 2002

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Cancer nanotechnology: opportunities and challenges (2005, background): “Dendritic polymers were demonstrated as multifunctional nanodevices with the ability to target folate in KB cells in culture, selectively deliver the cancer drug methotrexate intracellularly, and provide optical-imaging signals through the attachment of fluorescein to the nanovecto”
Magnetic nanoparticles in MR imaging and drug delivery. (2008, neutral): “multivalent attachment [124,145].”
Nanotechnological applications in medicine. (2007, background): “More recently, nanometer-sized constructs such as dendrimers [18,22,23], liposomes [24,25], nanoshells [26], nanotubes [27], nanoemulsions [28], quantum dots [29,30], and even viruses [31] have been developed as imaging agents intended as noninvasive probes or to target biomarkers of disease.”
Viruses and their uses in nanotechnology (2006, background): “Folate-conjugated dendrimers such as poly-amidoamine conjugated with folate were shown to be effective in tumor targeting and enhanced tumor cell uptake of methotrexate [Quintana et al., 2002].”
Nanotechnology: convergence with modern biology and medicine. (2003, background): “The use of nanoparticles for DNA delivery into cells [30,31].”