Alport's syndrome, Goodpasture's syndrome, and type IV collagen.

By B. Hudson, K. Tryggvason, M. Sundaramoorthy, Eric G. Neilson. New England Journal of Medicine, 2003

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Basement membranes: cell scaffoldings and signaling platforms. (2011, neutral): “When mutations develop in the genes coding for these subunits, leading to development of a GBM containing only a12a2 [IV] collagen, the GBM is thought to be destabilized leading to development of Alport syndrome (Hudson et al. 2003).”
Mammalian collagen IV (2008, background): “However, only three specific heterotrimers (α1α1α2, α3α4α5, and α5α5α6) have so far been found in all tissues studied (Borza et al., 2001; Boutaud et al., 2000; Hudson et al., 1994, 2003).”
The spectrum of podocytopathies: a unifying view of glomerular diseases. (2007, background): “podocyte, endothelial, and mesangial cells including the specialized a3, a4, and a5 type IV collagen chains.(16) The key organizational signaling systems required to”
Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development (2004, background): “Therefore, mutations in any of the genes coding for the α3(IV)α5(IV) chains cause tissue-specific phenotypes, associated with different forms of the Alport’s syndrome (Hudson et al., 2003; Tryggvason, 1996) or related diseases (Badenas et al., 2002; Buzza et al., 2001).”