TSGene: a web resource for tumor suppressor genes
By Min Zhao, Jingchun Sun, Zhongming Zhao. Nucleic Acids Res., 2012
342 citations recorded by the source corpus.
Tumor suppressor genes (TSGs) are guardian genes that play important roles in controlling cell proliferation processes such as cell-cycle checkpoints and inducing apoptosis. Identification of these genes and understanding their functions are critical for further investigation of tumorigenesis. So far, many studies have identified numerous TSGs and illustrated their functions in various types of tumors or normal samples. Furthermore, accumulating evidence has shown that non-coding RNAs can act as TSGs to prevent the tumorigenesis processes. Therefore, there is a growing demand to integrate TSGs with large-scale experimental evidence (e.g. gene expression and epigenetic signatures) to provide a comprehensive resource for further investigation of TSGs and their molecular mechanisms in cancer. To achieve this goal, we first developed a comprehensive literature-based database called TSGene (tumor suppressor gene database), freely available at http://bioinfo.mc.vanderbilt.edu/TSGene/. In the current release, TSGene contains 716 human (637 protein-coding and 79 non-coding genes), 628 mouse and 567 rat TSGs curated from UniProtKB, the Tumor Associated Gene database and 5795 PubMed abstracts. Additionally, the TSGene provides detailed annotations for each TSG, such as cancer mutations, gene expressions, methylation sites, TF regulations and protein–protein interactions.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c23a8ef18f76892171d826704aab1a0b6b0badee
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In Molecular Biology
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Citations in the corpus
- TSGene 2.0: an updated literature-based knowledgebase for tumor suppressor genes (2015, background): “0) in 2012 (13), and have been continuously maintaining it since then.”
- Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation (2014, background): “The first class was tumor suppressor genes: 18 of the top 50 genes, including six of the top seven, are known to have potent tumor suppressor activity (Vogelstein et al., 2013; Zhao et al., 2013).”
- Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance (2017, methodology): “M. Zhao, J. Sun, Z. Zhao, TSGene: A web resource for tumor suppressor genes.”