Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features.
By N. Zmora, Gili Zilberman-Schapira, Jotham Suez, Uria Mor, Mally Dori-Bachash, S. Bashiardes, E. Kotler, Maya Zur, Dana Regev-Lehavi, Rotem Ben-Zeev Brik and 16 more. Cell, 2018
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Empiric probiotics are commonly consumed by healthy individuals as means of life quality improvement and disease prevention. However, evidence of probiotic gut mucosal colonization efficacy remains sparse and controversial. We metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome. A sequential invasive multi-omics measurement at baseline and during consumption of an 11-strain probiotic combination or placebo demonstrated that probiotics remain viable upon gastrointestinal passage. In colonized, but not germ-free mice, probiotics encountered a marked mucosal colonization resistance. In contrast, humans featured person-, region- and strain-specific mucosal colonization patterns, hallmarked by predictive baseline host and microbiome features, but indistinguishable by probiotics presence in stool. Consequently, probiotics induced a transient, individualized impact on mucosal community structure and gut transcriptome. Collectively, empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa, meriting development of new personalized probiotic approaches.
Subfields: Food Science, Gastroenterology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c23a6e50dc5b1948b0080b146a78bd94c1860e85
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Citations in the corpus
- The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Findings from recent work showed that the ability of an introduced microbe to successfully colonize the gut depends on the structure of the resident gut microbiota (Zhang et al., 2016; Zmora et al., 2018), a factor that has so far been overlooked in microbial intervention–based clinical trials and t”
- Human gut microbiota/microbiome in health and diseases: a review (2020, background): “Zoetendal et al. (2001) studied the fecal microbiota of individuals with different degrees of genetic relatedness, ranging from monozygotic twins to unrelated individuals.”
- Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration (2019, background): “displayed that colonisation in the gut microbiota by probiotics occurs in highly individualised patterns, with engraftment occurring in some and not in others [49].”