Nanopore-based Fourth-generation DNA Sequencing Technology

By Yanxiao Feng, Yuechuan Zhang, C. Ying, Deqiang Wang, Chunlei Du. Genomics, Proteomics & Bioinformatics, 2015

399 citations recorded by the source corpus.

Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have the potential to quickly and reliably sequence the entire human genome for less than $1000, and possibly for even less than $100. The single-molecule techniques used by this technology allow us to further study the interaction between DNA and protein, as well as between protein and protein. Nanopore analysis opens a new door to molecular biology investigation at the single-molecule scale. In this article, we have reviewed academic achievements in nanopore technology from the past as well as the latest advances, including both biological and solid-state nanopores, and discussed their recent and potential applications.

Subfields: Biomedical Engineering, Computational Mechanics, Geophysics

View Paper: https://www.semanticscholar.org/paper/c1fc3c108341800d432e9f004e5f6bab4fa3b262

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In Biomedical Engineering

1. Sofia Valenzuela
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Citations in the corpus

• In‐field molecular diagnosis of plant pathogens: recent trends and future perspectives (2018, background): “However, the majority of NGS assays are done in specialized laboratories, require expensive equipment or service providers and require a great deal of sample preparation and complicated algorithms for data processing (Feng et al., 2015; Malapi-Wight et al., 2016).”