Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

By A. Holbrook, S. Schulman, D. Witt, P. Vandvik, Jason C. Fish, M. Kovacs, P. Svensson, D. Veenstra, M. Crowther, G. Guyatt. Chest, 2012

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The management of antithrombotic agents for patients undergoing GI endoscopy. (2016, background): “They also suggest the additional use of vitamin K be given (5-10 mg by slow IV) rather than reversal with coagulation factors alone.(85) PCC contains the vitamin K–dependent factors II, VII, IX, and X either in nonactivated form (nonactivated PCCs) or partially activated form (activated PCCs; indivi”
Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage (2016, background): “Benefits of PCC include its fast preparation and reconstitution time, rapid INR reversal, small volume, and lower risk of infection as compared to FFP [91, 92].”
Efficacy and Safety of a 4-Factor Prothrombin Complex Concentrate in Patients on Vitamin K Antagonists Presenting With Major Bleeding A Randomized, Plasma-Controlled, Phase IIIb Study (2013, background): “Nonactivated PCCs are lyophilized concentrates of VKDFs, referred to as 3-factor (contain significant quantities of factors II, IX, and X) or 4-factor (4F; also contain sufficient factor VII).7,11 PCCs can be administered promptly because of their relatively small infusion volume and because there i”