Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions.

By S. Soderling, J. Beavo. Current Opinion in Cell Biology, 2000

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GGDEF and EAL domains inversely regulate cyclic di‐GMP levels and transition from sessility to motility (2004, background): “…excert their effects by binding to different classes of proteins such as to transcriptional regulators, protein kinases, ion channels and even regulate their own synthesis by binding to phosphodiesterases and nucleotide cyclases (Kolb et al., 1993; Soderling and Beavo, 2000; Kopperud et al., 2003).”
PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “Cyclic nucleotide-specific PDEs are enzymes that hydrolyze the phosphodiester bond of cyclic nucleotides, thus playing an important role in the regulation of intracellular cyclic nucleotide levels (114, 157, 510).”
The MRP family of drug efflux pumps (2003, background): “…of intracellular cyclic nucleotide Oncogene levels because the precise time-sensitive signaling that is associated with these second messengers is thought to require immediate attenuation by the rapid, highcapacity system constituted by cellular phosphodiesterases (Soderling and Beavo, 2000).”