Confocal imaging-guided laser ablation of basal cell carcinomas: an ex vivo study

By Heidy Sierra, M. Cordova, C. Chen, M. Rajadhyaksha. Journal of Investigative Dermatology, 2014

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Laser ablation is a promising approach for minimally invasive removal of superficial and early nodular basal cell carcinomas (BCCs) (Smucler et al. , 2008, 2012). Skin can be removed in μm-thin layers in a well-controlled manner, increasing preservation of the surrounding normal tissue. However, tissue is vaporized such that there is none available for immediate histopathological confirmation. The efficacy tends to be variable and recurrence rate (8.25%) low (Smucler et al. , 2008), compared to that reported for Mohs surgery (2.1– 3.5%) (Chren et al. 2011, 2013), excision (3.5–4.2%) and electrodessication and curettage (1.6–4.9%). Thus, the implementation of laser ablation for BCCs in a clinical setting is still limited. A

Subfields: Dermatology, Epidemiology, Small Animals

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