Mediation Analysis with Multiple Mediators

By Tyler J. VanderWeele, Stijn Vansteelandt. Epidemiologic Methods, 2014

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Abstract Recent advances in the causal inference literature on mediation have extended traditional approaches to direct and indirect effects to settings that allow for interactions and non-linearities. In this article, these approaches from causal inference are further extended to settings in which multiple mediators may be of interest. Two analytic approaches, one based on regression and one based on weighting are proposed to estimate the effect mediated through multiple mediators and the effects through other pathways. The approaches proposed here accommodate exposure–mediator interactions and, to a certain extent, mediator–mediator interactions as well. The methods handle binary or continuous mediators and binary, continuous or count outcomes. When the mediators affect one another, the strategy of trying to assess direct and indirect effects one mediator at a time will in general fail; the approach given in this article can still be used. A characterization is moreover given as to when the sum of the mediated effects for multiple mediators considered separately will be equal to the mediated effect of all of the mediators considered jointly. The approach proposed in this article is robust to unmeasured common causes of two or more mediators.

Subfields: Sociology and Political Science, Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/c14194bb9bc01767eb0f966cc8f8414e069d1c41

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Citations in the corpus

Stigma and suicide risk among the LGBTQ population: Are anxiety and depression to blame and can connectedness to the LGBTQ community help? (2019, methodology): “As symptoms of depression and anxiety were hypothesized to be highly related and influencing one another, separate mediation analyses were run as opposed to a parallel mediation (VanderWeele & Vansteelandt, 2014).”
Mendelian randomisation for mediation analysis: current methods and challenges for implementation (2019, background): “Here, the coefficient for the exposure reflects the direct effect [31].”