Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

By G. Nikoloski, S. Langemeijer, R. Kuiper, Ruth Knops, Marion Massop, E. Tönnissen, A. Heijden, T. Scheele, P. Vandenberghe, T. Witte and 2 more. Nature Genetics, 2010

802 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c1214c96b52453036e8ed067d8cadefd53c72863

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Citations in the corpus

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation (2011, positive): “These include somatic mutations in chromatin-modifying enzymes (Ernst et al., 2010; Nikoloski et al., 2010) and in DNAmethyltransferases (Ley et al., 2010; Yamashita et al., 2010).”
A decade of exploring the cancer epigenome — biological and translational implications (2011, background): “Mutations in the histone-modifying enzyme EZH2, the catalytically active component of the PRC2 complex, have also been reporte”
Diagnosis and treatment of primary myelodysplastic syndromes in adults: recommendations from the European LeukemiaNet. (2013, background): “By using next-generation sequencing, in a proportion of patients with low-risk MDS and an isolated del(5q) mutation of TP53 was found that render them at higher risk for disease progression.”
Clonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia (2012, background): “This was followed by our studies of chronic myeloid leukemia where t(9;22) resulting in the BCR-ABL translocation occurred in HSCs, yielding chronic phase disease, yet progression to blast crisis was accompanied by additional mutations resulting in the formation of leukemia stem cells (LSCs) at the ”