The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.

By R. Shafi, S. Iyer, L. Ellies, Niall O’Donnell, Kurt W. Marek, D. Chui, Gerald W. Hart, J. Marth. Proceedings of the National Academy of Sciences of the United States of America, 2000

775 citations recorded by the source corpus.

Subfields: Economics and Econometrics, Finance

View Paper: https://www.semanticscholar.org/paper/c11d1626981f388315ba5670a6840eb1ce15e8b7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. A. Varki
2. Gerald W. Hart
3. Tai-ping Sun
4. F. Gubler
5. Chad Slawson
6. N. Olszewski
7. G. Ramirez-Correa
8. M. Housley

Citations in the corpus

• Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins (2007, background): “Gene disruption in mice established that OGT is required for embryonic-stem-cell viabilit”
• Gibberellin Signaling Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.010476. (2002, background): “Animals contain a single OGT gene, and deletion of the mouse OGT gene results in embryo lethality (Shafi et al., 2000), indicating that O-GlcNAc modification of proteins is essential.”
• Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease (2011, background): “OGT maps to a locus near the centromere on the X-chromosome (58) (human Xq13.”
• Biological roles of glycans (2016, background): “When embryonic lethality makes it difficult to define specific biological roles, tissue-specific targeted genetic alterations became important (428) (429) (430) .”