Magnetic Resonance Elastography of Liver: Technique, Analysis and Clinical Applications
By Sudhakar Kundapur Venkatesh, M. Yin, R. Ehman. Journal of Magnetic Resonance Imaging, 2013
675 citations recorded by the source corpus.
Many pathological processes cause marked changes in the mechanical properties of tissue. MR elastography (MRE) is a noninvasive MRI based technique for quantitatively assessing the mechanical properties of tissues in vivo. MRE is performed by using a vibration source to generate low frequency mechanical waves in tissue, imaging the propagating waves using a phase contrast MRI technique, and then processing the wave information to generate quantitative images showing mechanical properties such as tissue stiffness. Since its first description in 1995, published studies have explored many potential clinical applications including brain, thyroid, lung, heart, breast, and skeletal muscle imaging. However, the best‐documented application to emerge has been the use of MRE to assess liver disease. Multiple studies have demonstrated that there is a strong correlation between MRE‐measured hepatic stiffness and the stage of fibrosis at histology. The emerging literature indicates that MRE can serve as a safer, less expensive, and potentially more accurate alternative to invasive liver biopsy which is currently the gold standard for diagnosis and staging of liver fibrosis. This review describes the basic principles, technique of performing a liver MRE, analysis and calculation of stiffness, clinical applications, limitations, and potential future applications. J. Magn. Reson. Imaging 2013;37:544–555. © 2012 Wiley Periodicals, Inc.
Subfields: Biomedical Engineering, Epidemiology, Radiology, Nuclear Medicine and Imaging
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Citations in the corpus
- Diagnosis and Management of Autoimmune Hepatitis in Adults and Children: 2019 Practice Guidance and Guidelines From the American Association for the Study of Liver Diseases (2019, background): “The findings of magnetic resonance elastography (MRE) correlate strongly with fibrosis stage, and MRE appears to outperform VCTE for staging hepatic fibrosis in some studies performed in other liver diseases.(266-269) Furthermore, MRE assessment of splenic stiffness can have prognostic value for pre”
- Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography. (2016, background): “In contrast, because MRE uses compressional and continuous waves, the elastic waves generated by the vibrator could be effective in patients with ascites or obesity, including patients with a BMI >28 kg/m 2 [50].”
- AI in Medical Imaging Informatics: Current Challenges and Future Directions (2020, positive): “Moreover, Magnetic Resonance Elastography (MRE) allows virtual palpation with significant applications in liver fibrosis [20], while 4D flow methods permit exquisite visualization of flow in 3D + t [17], [21].”