Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges
By D. Ha, Ningning Yang, Venkatareddy Nadithe. Acta Pharmaceutica Sinica B, 2016
1,198 citations recorded by the source corpus.
Exosomes are small intracellular membrane-based vesicles with different compositions that are involved in several biological and pathological processes. The exploitation of exosomes as drug delivery vehicles offers important advantages compared to other nanoparticulate drug delivery systems such as liposomes and polymeric nanoparticles; exosomes are non-immunogenic in nature due to similar composition as body׳s own cells. In this article, the origin and structure of exosomes as well as their biological functions are outlined. We will then focus on specific applications of exosomes as drug delivery systems in pharmaceutical drug development. An overview of the advantages and challenges faced when using exosomes as a pharmaceutical drug delivery vehicles will also be discussed.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/c0e333f33d9e9aae7728b267f91bb0925c3b9483
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In Molecular Biology
Citations in the corpus
- The exosome journey: from biogenesis to uptake and intracellular signalling (2021, background): “Cytoskeletal proteins Actin, Cofilin, Tubulin Exosome biogenesis and secretion [16, 19, 30]”
- Current Strategies for Brain Drug Delivery (2018, background): “Brain permeability enhancer Transiently open the BBB Mismatch between findings in rodents and humans [54-58],”
- Designer exosomes produced by implanted cells intracerebrally deliver therapeutic cargo for Parkinson’s disease treatment (2018, neutral): “Since exosomes can cross the blood-brain barrier 4 – 6, 29 , we assessed whether Intracerebral delivery of exosomal mRNA from implant in mice .”