Diabetic neuropathy: Clinical manifestations and current treatments
By B. Callaghan, Hsinlin T. Cheng, C. Stables, Andrea L. Smith, Eva L. Feldman. Lancet Neurology, 2012
1,100 citations recorded by the source corpus.
Diabetic peripheral neuropathy is a prevalent, disabling condition. The most common manifestation is a distal symmetric polyneuropathy (DSP), but many patterns of nerve injury can occur. Currently, the only effective treatments are glucose control and pain management. While glucose control dramatically decreases the development of neuropathy in those with type 1 diabetes, the effect is likely much smaller in those with type 2 diabetes. High levels of evidence support the use of certain anticonvulsants and antidepressants for pain management in diabetic peripheral neuropathy. However, the lack of disease modifying therapies for diabetic DSP makes the identification of new modifiable risk factors essential. Intriguingly, growing evidence supports an association between metabolic syndrome components, including pre-diabetes, and neuropathy. Future studies are needed to further explore this relationship with implications for new treatments for this common disease.
Subfields: Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/c0959588a4f689bbd262e9982ea3515344350e9b
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In Neurology
Citations in the corpus
- Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial (2013, neutral): “Performance status 0 60 (55) 60 (54) 120 (55)”
- Diabetic Neuropathy: A Position Statement by the American Diabetes Association (2016, background): “Although there are broad general agreements among the recommendations, there are some inconsistencies that are, in part, a consequence of whether the guidelines are specific for painful DSPN or whether they address neuropathic pain due to all causes (15,16,20,86,87).”