Distinct Ensemble Codes in Hippocampal Areas CA3 and CA1

By Stefan Leutgeb, J. Leutgeb, Alessandro Treves, May-Britt Moser, Edvard I. Moser. 2004

790 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

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Citations in the corpus

Generalization Through the Recurrent Interaction of Episodic Memories (2012, background): “Experimental data support the idea that layers deep within the hippocampus (e.g., dentate gyrus and the CA3 region) may play the role of our conjunctive layer (e.g., S. Leutgeb et al., 2004; McHugh et al., 2007).”
Hippocampal replay in the awake state: a potential physiological substrate of memory consolidation and retrieval (2011, background): “In general, hippocampal place cells form unique maps of each experienced environment, and only about 40–50% of CA1 place cells are active in any given environmen”
Entorhinal Cortical Ocean Cells Encode Specific Contexts and Drive Context-Specific Fear Memory. (2015, positive): “These theories were supported by subsequent experimental data on the physiological response of CA3 pyramidal cells (PCs) to switching between a pair of similar contexts (Leutgeb et al., 2007; Leutgeb et al., 2004; McHugh et al., 2007; Wintzer et al., 2014), and on the behavioral performance of mice ”
Place cells, grid cells, and the brain's spatial representation system. (2008, background): “The disambiguation of the firing patterns is stronger in CA3 than in CA1 (Leutgeb et al. 2004, Vazdarjanova & Guzowski 2004).”
Neural Ensembles in CA3 Transiently Encode Paths Forward of the Animal at a Decision Point (2007, background): “Place fields were defined as a contiguous region with an average firing rate exceeding 20% peak field rate (Huxter et al., 2003; Leutgeb et al., 2004).”
Memory Engram Cells Have Come of Age. (2015, positive): “Semon’s concept about memory retrieval is evidence for his amazing insightfulness, because it is nothing but the process of “pattern completion” theorized (Marr, 1970) and experimentally demonstrated many decades later (Leutgeb et al., 2004; Nakazawa et al., 2003).”
Network dynamics underlying the formation of sparse, informative representations in the hippocampus (2008, positive): “Importantly, only 40% of the principal neurons in hippocampal area CA1 and 30% of the principal neurons in upstream area CA3 (Wilson and McNaughton, 1993; Lee et al., 2004b; Leutgeb et al., 2004) show clear spatial specificity in a given familiar environment whereas the rest are essentially silent.”
Temporal encoding of place sequences by hippocampal cell assemblies. (2006, background): “Cooperation of CA3 and CA1 Assemblies Recent studies have emphasized the distinct functional roles of CA3 and CA1 neurons (Leutgeb et al., 2004; Lee et al., 2004a, 2004b).”
Timing and efficacy of transmitter release at mossy fiber synapses in the hippocampal network (2006, neutral): “Experimental evidence for pattern separation is that CA3 cells show abrupt and coordinated place field remapping when the environment is changed to a larger extent [51, 77, 85].”
Rewarded Outcomes Enhance Reactivation of Experience in the Hippocampus (2009, positive): “This pairwise measure was necessary because CA3 tends to be sparsely active (Leutgeb et al., 2004) and, as our goal was to record for many days, we did not maximize the number of simultaneously recorded cells on a single day.”
Theta rhythm of navigation: Link between path integration and landmark navigation, episodic and semantic memory (2005, background): “Subsequent work has described multiple, interconnected maps in the dentate, CA3 and CA1 regions, and the EC (Quirk et al., 1992; Jung and McNaughton, 1993; cf. Muller, 1996; Frank et al., 2000; Fyhn et al., 2004; Lee et al., 2004; Leutgeb et al., 2004).”
Pattern separation in the hippocampus through the eyes of computational modeling (2017, background): “…similar inputs can be achieved via the generation of different activity patterns, either through the activation of distinct sets of neurons or via the modulation of the firing rates in the same population of neurons (Deng, Aimone, & Gage, 2010; Deng, Mayford, & Gage, 2013; Leutgeb et al., 2004).”