Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery
By Yu-miao Zhao, Yao-min Shang, Wenxing Song, Qing-quan Li, Hua Xie, Qin-fu Xu, Junlu Jia, Li-ming Li, Hong-li Mao, Xiu-man Zhou and 3 more. EClinicalMedicine, 2020
809 citations recorded by the source corpus.
Background The long-term pulmonary function and related physiological characteristics of COVID-19 survivors have not been studied in depth, thus many aspects are not understood. Methods COVID-19 survivors were recruited for high resolution computed tomography (HRCT) of the thorax, lung function and serum levels of SARS-CoV-2 IgG antibody tests 3 months after discharge. The relationship between the clinical characteristics and the pulmonary function or CT scores were investigated. Findings Fifty-five recovered patients participated in this study. SARS-CoV-2 infection related symptoms were detected in 35 of them and different degrees of radiological abnormalities were detected in 39 patients. Urea nitrogen concentration at admission was associated with the presence of CT abnormalities (P = 0.046, OR 7.149, 95% CI 1.038 to 49.216). Lung function abnormalities were detected in 14 patients and the measurement of D-dimer levels at admission may be useful for prediction of impaired diffusion defect (P = 0.031, OR 1.066, 95% CI 1.006 to 1.129). Of all the subjects, 47 of 55 patients tested positive for SARS-CoV-2 IgG in serum, among which the generation of Immunoglobulin G (IgG) antibody in female patients was stronger than male patients in infection rehabilitation phase. Interpretation Radiological and physiological abnormalities were still found in a considerable proportion of COVID-19 survivors without critical cases 3 months after discharge. Higher level of D-dimer on admission could effectively predict impaired DLCO after 3 months discharge. It is necessary to follow up the COVID-19 patients to appropriately manage any persistent or emerging long-term sequelae. Funding Key Scientific Research Projects of Henan Higher Education Institutions
Subfields: Infectious Diseases, Neurology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/c07320bee994d09ddca9a622aaef34d99cc52944
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Citations in the corpus
- Symptoms, complications and management of long COVID: a review (2021, background): “Persistent symptoms were also reported by 64% of the patients.(34) Ground glass opacity was the most common high-resolution computed tomography pattern observed in the study by Huang et al.”
- Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis (2021, neutral): “…of Outcomes Results Factors Associated with persistent symptoms 184 healthy controls) ● Age range: 20–80 ● Median age: 52 (41–62) ● Sex (%F/%M): 30.3/ 69.7 conducted by three experienced clinicians (34% [52/152] males; 66% [100/152] females) than male subjects, and in those aged 41–60 Zhao…”
- Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments (2021, background): “Biomarkers Elevated blood urea nitrogen (BUN) and D-dimer levels were found to be risk factors for pulmonary dysfunction among survivors of COVID-19 at three-month post-hos-pital discharge [46].”
- More Than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis (2021, neutral): “5 (19-84) 63 Fatigue, dyspnea, joint pain, chest pain, cough, anosmia, Sicca syndrome, Rhinitis, red eyes, dysgeusia, headache, sputum, lack of appetite, sore throat, vertigo, myalgia, diarrhea.”