Angiogenesis and bone repair.

By R. Carano, E. Filvaroff. Drug Discovery Today, 2003

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Strategies for Controlled Delivery of Growth Factors and Cells for Bone Regeneration (2012, background): “Systemic Factors—Since bone injuries also involve a systemic physiological response, the therapeutic role of systemic factors such as parathyroid hormone (PTH), growth hormone, steroids, calcitonin and Vitamin D in osteogenesis and angiogenesis have also been considered [52].”
Self-healing polymeric materials: A review of recent developments (2008, background): “The repair mechanisms for bone [216], tendons [217] and skin [213] in humans are also based on a multi-mechanistic approach, involving initial inflammatory responses in conjunction with the regeneration of the damaged material.”
Osteogenesis and angiogenesis: the potential for engineering bone. (2008, background): “These include Bone Morphogenic Proteins (BMP), fibroblast growth factors, prostaglandins, VEGF, platelet derived growth factors, PTH, insulin growth factor-1, reactive oxygen and nitrogen species (Carano and Filvaroff, 2003; Kanczler et al., 2003, Zheng et al., 2006).”
Sequential delivery of immunomodulatory cytokines to facilitate the M1-to-M2 transition of macrophages and enhance vascularization of bone scaffolds (2014, neutral): “Bone is unique in that small fractures heal perfectly, without scarring [25], while large bone defects remain a significant challenge [26].”