Intensity of continuous renal-replacement therapy in critically ill patients.

By R. Bellomo, A. Cass, L. Cole, S. Finfer, M. Gallagher, Serigne Lo, C. McArthur, S. McGuinness, J. Myburgh, Robyn Norton and 2 more. New England Journal of Medicine, 2009

871 citations recorded by the source corpus.

Subfields: Nephrology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/bf3b73f4b7ab1e641e068629bd379feb6c2b2ae5

How researchers see this paper

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In Nephrology

1. R. Bellomo
2. John A. Kellum
3. L. Chawla
4. Claudio Ronco

Citations in the corpus

• Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance (2021, background): “No effective therapy has been established, although many pharmacologic therapies such as diuretics, vasoactive drugs, and growth factors have been reported in animal models or preliminary clinical studies [9,10].”
• Hepatorenal syndrome: the 8th international consensus conference of the Acute Dialysis Quality Initiative (ADQI) Group (2012, background): “Although there is a preference for continuous renal replacement therapy (CRRT) over intermittent hemodialysis in hemodynamically unstable patients [89-93], analysis of the currently published studies does not allow evidence-based guidelines for the selection of RRT modality for the treatment of AKI ”
• Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 (2017, background): “Two large, multicenter, randomized trials comparing the dose of renal replacement (Acute Renal Failure Trial Network in the United States and RENAL Study in Australia and New Zealand) also failed to show benefit of more aggressive renal replacement dosing [506, 507].”
• KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. (2013, methodology): “For example, severe AKI occurs in 5% of critically ill patients and is associated with mortality rates of 40%-70%.(10-12) Although recovery of kidney function occurs in the majority of patients surviving an episode of AKI, many patients remain dialysis dependent or are left with severe renal impairm”