Ferroptosis: A Novel Anti-tumor Action for Cisplatin

By Jipeng Guo, Bingfei Xu, Q. Han, Hongxia Zhou, Yun Xia, C. Gong, X. Dai, Zhenyu Li, Gang Wu. Cancer research and treatment : official journal of Korean Cancer Association, 2017

682 citations recorded by the source corpus.

Purpose Ferroptosis is a new mode of regulated cell death, which is completely distinct from other cell death modes based on morphological, biochemical, and genetic criteria. This study evaluated the therapeutic role of ferroptosis in classic chemotherapy drugs, including the underlying mechanism. Materials and Methods Cell viabilitywas detected by using the methylthiazoltetrazlium dye uptake method. RNAiwas used to knockout iron-responsive element binding protein 2, and polymerase chain reaction, western blot was used to evaluate the efficiency. Intracellular reduced glutathione level and glutathione peroxidases activitywere determined by related assay kit. Intracellularreactive oxygen species levelswere determined by flowcytometry. Electron microscopywas used to observe ultrastructure changes in cell. Results Among five chemotherapeutic drugs screened in this study, cisplatin was found to be an inducer for both ferroptosis and apoptosis in A549 and HCT116 cells. The depletion of reduced glutathione caused by cisplatin and the inactivation of glutathione peroxidase played the vital role in the underlying mechanism. Besides, combination therapy of cisplatin and erastin showed significant synergistic effect on their anti-tumor activity. Conclusion Ferroptosis had great potential to become a new approach in anti-tumor therapies and make up for some classic drugs, which open up a new way for their utility in clinic.

Subfields: Molecular Biology, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/bf123104514038bae87fee00455d295b979ebdc7

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Citations in the corpus

Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “373 410 – 413 Combining cisplatin with FINs also may be a better strategy to improve the therapeutic effect of cisplatin.”
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. (2017, positive): “…(BSO) depletes glutathione, and in some cases is capable of inducing ferroptosis (Yang et al., 2014); CCl4 may induce ferroptosis in the liver (Guo et al., 2017), artesunate can induce ferroptosis in pancreatic cancer cells (Eling et al., 2015), cisplatin induces both ferroptosis and…”