Early identification of refractory epilepsy.

By Patrick S L Kwan, M. Brodie. New England Journal of Medicine, 2000

4,907 citations recorded by the source corpus.

Subfields: Pediatrics, Perinatology and Child Health, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/beb3708a493417c4c3ff8f822db84b7cabf18658

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pediatrics, Perinatology and Child Health

1. Wolfgang Löscher
2. Patrick Kwan
3. Heidrun Potschka
4. D. Liew
5. Zhibin Chen
6. M. Brodie

In Psychiatry and Mental health

1. Heidrun Potschka
2. Wolfgang Löscher
3. Patrick Kwan
4. D. Liew
5. Zhibin Chen
6. M. Brodie

Citations in the corpus

• The gut microbiota mediates the anti-seizure effects of the ketogenic diet (2018, neutral): “The low-carbohydrate, high-fat ketogenic diet (KD) is an effective treatment for refractory epilepsy, a condition affecting more than one-third of epileptic individuals and defined by a failure to respond to existing anticonvulsant medications (Kwan and Brodie, 2000).”
• Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy. (2014, background): “This is an open access article under last decades, one-third of people with epilepsy continue to have seizures despite treatment [3].”
• The consequences of refractory epilepsy and its treatment. (2014, background): “Approximately 60% of patients with epilepsy will become seizure-free with the first one to two AEDs, and approximately 4% with further AED trials [43].”
• Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies (2009, background): “Observational cohort studies of newly diagnosed epilepsy in adults (Kwan & Brodie, 2000; Mohanraj & Brodie, 2006) and children (Arts et al., 2004) suggest that once a patient has failed trials of two appropriate AEDs, the probability of achieving seizure freedom with subsequent AED treatments is…”
• Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: A 30-Year Longitudinal Cohort Study (2017, methodology): “0%).(3) However, theoverall seizure-freerate in thisstudywasslightly lower than the rate (68.”
• Adaptive control of epileptiform excitability in an in vitro model of limbic seizures (2013, neutral): “Epilepsy is a highly-prevalent chronic neurological disorder (Kotsopoulos, et al., 2002) and up to 30% of epilepsy patients do not respond to pharmacological treatment (Kwan and Brodie, 2000).”
• Chronic epilepsy and cognition: A longitudinal study in temporal lobe epilepsy (2003, background): “Despite recent advances in the diagnosis and pharmacological treatment of localization-related epilepsy, seizures remain refractory to medical therapy in approximately 30% of patients.(1) Deteriorating memory and cognitive abilities have been described in chronic epilepsy, but it remains controversi”
• Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy (2010, background): “Epilepsy has a prevalence of approximately 1% in the world’s population, and approximately one-third of people with epilepsy do not respond adequately to antiepileptic drugs (AEDs) (Kwan & Brodie, 2000).”
• Adaptive Control of Epileptic Seizures using Reinforcement Learning (2010, background): “Up to 30% of epilepsy patients suffer from refractory epilepsy [39], meaning that anti-epileptic medications are not effective on those patients.”
• Drug resistance in brain diseases and the role of drug efflux transporters (2005, background): “, about one-third of patients with epilepsy are RESISTANT to drug treatmen”