Molecular architecture and assembly of the DDB1–CUL4A ubiquitin ligase machinery

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Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses (2021, methodology): “The quality of the 3D volumes was sufficient to fit crystallographic models of core (Fig 2) and the stalk (PDB 2hye) [15] as rigid bodies (Figs 3B and S4G).”
Structure and function of WD40 domain proteins (2011, background): “It shares a conserved molecular architecture with other SCF ubiquitin ligases (Fig. 3B) ( Angers et al., 2006 ).”
Defining the human C2H2 zinc-finger degrome targeted by thalidomide analogs through CRBN (2018, background): “Given the CRL4 protein architecture and its ~100-Å ubiquitination radius (6, 7, 22), we expect degradation of fulllength ZF proteins to be less dependent on lysine accessibility and instead primarily determined by the protein synthesis rate and the affinity and binding kinetics of the internal ZF de”