The role of interleukin-2 during homeostasis and activation of the immune system

By O. Boyman, J. Sprent. Nature reviews. Immunology, 2012

1,676 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy (2013, positive): “…(IL-2) was first discovered over 35 years ago as an activity present in supernatants of activated human T cells that mediates T cell growth and proliferation (Morgan et al., 1976; previously reviewed in Boyman and Sprent, 2012; Kim et al., 2006; Lin and Leonard, 2000; Malek and Castro, 2010).”
Unraveling the Complex Interplay Between T Cell Metabolism and Function (2018, background): “This decreased mTOR and c-Myc activity can be alleviated by exposure to IL-2 from activated CD4+ effector T (Te) cells (18).”
Anchoring of intratumorally administered cytokines to collagen safely potentiates systemic cancer immunotherapy (2019, background): “Collagen-anchored IL-2 potentiates efficacy of a tumortargeting antibody IL-2 is a compelling candidate for tumor localization because its antitumor efficacy requires sustaining a high intratumoral concentration (15).”