Evidence for an increased rate of cardiovascular events in patients with primary aldosteronism.

By P. Milliez, X. Girerd, P. Plouin, J. Blacher, M. Safar, J. Mourad. Journal of the American College of Cardiology, 2005

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Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. (2008, background): “Patients ith primary hyperaldosteronism have an increased incience of AF (45), and locally produced AngII is associated ith cardiomyocyte apoptosis and reactive interstitial fibrois (46).”
Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. (2008, background): “Why is PA important? This condition is important not only because of its prevalence but also because PA patients have higher cardiovascular morbidity and mortality than age- and sex-matched patients with essential hypertension and the same degree of blood pressure elevation (21, 22).”
The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline. (2016, background): “Several outcome studies also have provided evidence that PA patients are particularly at risk of cardiovascular/ renal complications, including arrhythmias, myocardial infarction, strokes, chronic kidney disease, and death, compared with age-, sex-, and BP-matched essential hypertensives (30, 33, 15”