Understanding Ras: 'it ain't over 'til it's over'.

By J. M. Shields, Kevin Pruitt, Aidan McFall, A. Shaub, C. Der. Trends in Cell Biology, 2000

821 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/be914b31a69fd4ea085551cba68c90a2c84d5723

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In Molecular Biology

Citations in the corpus

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer (2007, background): “There is substantial evidence validating the importance of Raf and MEK in cancer progression and in promoting cancer growth (Shields et al., 2000).”
Targeting the Mitogen-Activated Protein Kinase RAS-RAF Signaling Pathway in Cancer Therapy (2012, background): “Accordingly, Ras communicates external cellular signals to the nucleus, and its altered activation leads to inappropriate cellular activities including enhanced cell growth, differentiation, survival and ultimately to cancer [1,8,9].”
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth (2015, background): “In this state Ras stimulates downstream effectors that increase proliferation, block differentiation, reprogrammetabolism, and suppress apoptosis to drive oncogenesis (Shields et al., 2000).”
Phosphorylation: Implications in Cancer (2017, background): “In addition, the importance of Raf and MEK in cancer progression and in promoting cancer growth has been well established [31].”
Species- and cell type-specific requirements for cellular transformation. (2004, methodology): “…evidence suggests that there may be cell type-specific measure the activation of Ral-GEFs, we measured the activation of their downstream component Ral by performing GTP-Raldifferences in the requirements of Ras effectors for cellular transformation (Hamad et al., 2002; Shields et al., 2000).”
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. (2003, background): “The cellular effects of oncogenic RAS have been shown to be exquisitely dependent upon both the levels and context of RAS expression in a number of experimental systems (Shields et al., 2000).”