Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B.
By J. Kao, Pei‐Jer Chen, M. Lai, Ding‐Shinn Chen. Gastroenterology, 2000
968 citations recorded by the source corpus.
BACKGROUND & AIMS Six genotypes (A-F) of hepatitis B virus (HBV) have been identified; however, the genotype-related differences in the pathogenicity of HBV remain unknown. Therefore, we investigated the prevalence of HBV genotypes in Taiwan and the association between distinct genotypes and severity of liver disease in a cross-sectional study. METHODS Using a molecular method, HBV genotypes were determined in 100 asymptomatic carriers and in 170 patients with histologically verified chronic liver disease and hepatocellular carcinoma (HCC). RESULTS All genotypes except genotype E were identified in Taiwan, and genotypes B and C were predominant. Genotype C was prevalent in patients with cirrhosis and in those with HCC who were older than 50 years compared with age-matched asymptomatic carriers (60% vs. 23%, P < 0.001, and 41% vs. 15%, P = 0.005, respectively). Genotype B was significantly more common in patients with HCC aged less than 50 years compared with age-matched asymptomatic carriers (80% vs. 52%, P = 0.03). This predominance was more marked in younger patients with HCC (90% in those aged </=35 years), most of whom did not have cirrhosis. CONCLUSIONS Our data suggest that HBV genotype C is associated with more severe liver disease and genotype B may be associated with the development of HCC in young Taiwanese. However, additional large-scale longitudinal studies are needed to confirm the relationship of HBV genotypes to liver disease severity and clinical outcomes.
Subfields: Epidemiology, Hepatology
View Paper: https://www.semanticscholar.org/paper/be499a65592efa2305b9ce78aad42b7a0562496c
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Citations in the corpus
- iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “, 2004), reactivation of HBV (Chu & Liaw, 2005, 2007), end-stage liver disease (Kao et al., 2000; Chan et al., 2003; Chu & Liaw, 2005), and HCC (Yu et al.”
- Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma (2010, background): “Studies have now shown that HBV genotype correlates with the risk for HCC and that genotype C carries two- to threefold higher risk than genotype B in developing HCC [10, 14–19].”
- Epidemiology and Prevention of Hepatitis B Virus Infection (2005, background): “HBV carriers with genotype B have lower histologic activity scores [37], and genotype C is more prevalence in patients with cirrhosis [38,39].”
- Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 update (2015, background): “Additional factors have been identified to be associated with progression to cirrhosis: habitual alcohol intake, concurrent infection with hepatitis C virus (HCV) or human immunodeficiency virus (HIV), high levels of HBV replication, and patients who had HBeAg reversion, HBV genotype (C[B) [67, 68] ”
- Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update (2017, background): “In multiple population-based studies, genotype C has been associated with higher risk of HCC than genotypes A, B, and D [20, 21].”