Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

By M. Cowley, James L. Smart, M. Rubinstein, Marcelo G. Cerdán, S. Diano, T. Horvath, Roger Cone, M. Low. Nature, 2001

2,376 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/be1fdf4847ca0fc7600e538781591bad90509edd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Roger Cone
2. A. N. van den Pol
3. Matthias Tschöp
4. M. Heiman
5. Bradford B. Lowell
6. M. Myers
7. C. Ye
8. K. Kangawa

In Epidemiology

1. Roger Cone
2. M. Myers

In Nutrition and Dietetics

1. Roger Cone
2. A. N. van den Pol
3. Matthias Tschöp
4. M. Heiman
5. Bradford B. Lowell
6. M. Myers
7. K. Kangawa

Citations in the corpus

• Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity (2017, neutral): “Thereby, this structure interconnects key nuclei of the limbic system with hypothalamic and brainstem structures in both rodents and humans (for reviews, see Crestani et al., 2013; Avery et al., 2016).”
• The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. (2003, methodology): “Coincident with its effect on the spontaneous ac- (Cowley et al., 2001) and correlate temporally with the increase in the activity of NPY neurons shown in Figuretivity of NPY neurons, ghrelin also depolarized identified NPY neurons (11.8 2.1 mV; n 3).”
• Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons (2011, positive): “, 1999), and leptin, which promotes negative energy balance, inhibits AgRP neurons and excites POMC neurons (Cowley et al., 2001; Elias et al., 1999; Takahashi and Cone, 2005; van den Top et al., 2004).”
• Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. (2015, background): “The fall in leptin stimulates the expression of AgRP and NPY and suppresses POMC and CART, thereby increasing food intake and decreasing energy expenditure [21, 22].”
• Constitutive and Synaptic Activation of GIRK Channels Differentiates Mature and Newborn Dentate Granule Cells (2018, methodology): “To identify newly generated adultborn GCs, we used reporter mice with enhanced green fluorescent protein (EGFP) expressed under the control of the proopiomelanocortin (POMC) promoter (POMC-EGFP; Cowley et al., 2001; Overstreet et al., 2004), or GFP expressed under the control of the glutamate decarb”