Continuous Flow Driven Inversion for Arterial Spin Labeling Using Pulsed Radiofrequency and Gradient Fields

By Weiying Dai, Dairon Garcia, C. De Bazelaire, David C Alsop. Magnetic Resonance in Medicine, 2008

1,038 citations recorded by the source corpus.

Continuous labeling by flow‐driven adiabatic inversion is advantageous for arterial spin labeling (ASL) perfusion studies, but details of the implementation, including inefficiency, magnetization transfer, and limited support for continuous‐mode operation on clinical scanners, have restricted the benefits of this approach. Here a new approach to continuous labeling that employs rapidly repeated gradient and radio frequency (RF) pulses to achieve continuous labeling with high efficiency is characterized. The theoretical underpinnings, numerical simulations, and in vivo implementation of this pulsed continuous ASL (PCASL) method are described. In vivo PCASL labeling efficiency of 96% relative to continuous labeling with comparable labeling parameters far exceeded the 33% duty cycle of the PCASL RF pulses. Imaging at 3T with body coil transmission was readily achieved. This technique should help to realize the benefits of continuous labeling in clinical imagers. Magn Reson Med 60:1488–1497, 2008. © 2008 Wiley‐Liss, Inc.

Subfields: Atomic and Molecular Physics, and Optics, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/bdf479556ee32ff26a133f83819c54e29762552a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Atomic and Molecular Physics, and Optics

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Recommended Implementation of Arterial Spin Labeled Perfusion MRI for Clinical Applications: A consensus of the ISMRM Perfusion Study Group and the European Consortium for ASL in Dementia (2014, methodology): “ASL labeling approaches can be grouped into three types: continuous labeling (7,8,17),”
Estimation of Perfusion Properties with MR Fingerprinting Arterial Spin Labeling (2018, methodology): “In order to use an MRF approach to gain sensitivity to these parameters, the MRF ASL pulse sequence used was a pseudo-continuous arterial spin labeling (pCASL) scheme [24,25].”
Imaging Brain Fatigue from Sustained Mental Workload: An ASL Perfusion Study of the Time-On-Task Effect (2009, methodology): “A pseudo-continuous ASL sequence (Wu et al., 2007; Dai et al., 2008) was used for the perfusion scan.”
SynthStrip: skull-stripping for any brain image (2022, positive): “In-house, pseudo-continuous ASL (PCASL) scans are acquired as stacks of 2D-EPI slices with low resolution and a small FOV that often crops the ventral brain region (Dai et al., 2008).”
Age-Associated Reductions in Cerebral Blood Flow Are Independent from Regional Atrophy (2010, background): “…requiring no exogenous tracers, and continuous ASL (CASL) (Detre et al., 1992, 1994, 1998a,b) as well as the more novel pseudo-continuous ASL (Dai et al., 2008b; Silva and Kim, 1999) have recently found application in clinical populations (Alsop et al., 2008, 2010; Detre et al., 1998a,b; Xu…”
Effects of transcranial direct current stimulation (tDCS) on human regional cerebral blood flow (2011, methodology): “Each ASL scan required approximately 3.5 min and the acquisition of a reference image for rCBF quantification added an additional minute to the acquisition (Dai et al., 2008).”