Articular cartilage and changes in Arthritis: Cell biology of osteoarthritis
By L. Sandell, T. Aigner. Arthritis Research & Therapy, 2001
783 citations recorded by the source corpus.
The reaction patterns of chondrocytes in osteoarthritis can be summarized in five categories: (1) proliferation and cell death (apoptosis); changes in (2) synthetic activity and (3) degradation; (4) phenotypic modulation of the articular chondrocytes; and (5) formation of osteophytes. In osteoarthritis, the primary responses are reinitiation of synthesis of cartilage macromolecules, the initiation of synthesis of types IIA and III procollagens as markers of a more primitive phenotype, and synthesis of active proteolytic enzymes. Reversion to a fibroblast-like phenotype, known as 'dedifferentiation', does not appear to be an important component. Proliferation plays a role in forming characteristic chondrocyte clusters near the surface, while apoptosis probably occurs primarily in the calcified cartilage.
Subfields: Immunology and Allergy, Pharmacology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/bdd7593ecad6c0fd4c4fa545868abf79d86e37e1
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Citations in the corpus
- Significant association of interleukin-4 gene intron 3 VNTR polymorphism with susceptibility to knee osteoarthritis. (2014, background): “Ultimately, chondrocyte malfunction and apoptosis limit the response potential and hasten the progression of OA (Pelletier et al., 2001; Sandell and Aigner, 2001).”