Experimental pulmonary edema due to intermittent positive pressure ventilation with high inflation pressures. Protection by positive end-expiratory pressure.

By H. H. Webb, D. Tierney. American Review of Respiratory Disease, 2015

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Pulmonary Atelectasis: A Pathogenic Perioperative Entity (2005, background): “In a surfactant deactivation model of acute respiratory distress syndrome (ARDS), they measured alveolar number and stability before, during, and after a recruitment maneuver with ventilation with either decreased or increased PEEP.”
Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. (2008, background): “Injury due to mechanical ventilation has been attributed to excessive pressure (barotrauma [1, 2]) or volume (volutrauma [3]) applied to the lung parenchyma, to shear stresses occurring at the interface of open and closed lung regions (atelectrauma [4, 5]), and to cellular inflammatory response (bio”
A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: A randomized, controlled trial* (2006, background): “We speculate that the improved mortality observed in the Pflex/LTV group is a result of two mechanisms: a higher PEEP level and a lower VT and plateau pressure, the high PEEP preventing recruitment-derecruitment injury (3, 24) and the lower VT and plateau pressure avoiding overdistension injury (7, ”