Stimuli-responsive nanocarriers for drug delivery, tumor imaging, therapy and theranostics

By P. Mi. Theranostics, 2020

620 citations recorded by the source corpus.

In recent years, much progress has been motivated in stimuli-responsive nanocarriers, which could response to the intrinsic physicochemical and pathological factors in diseased regions to increase the specificity of drug delivery. Currently, numerous nanocarriers have been engineered with physicochemical changes in responding to external stimuli, such as ultrasound, thermal, light and magnetic field, as well as internal stimuli, including pH, redox potential, hypoxia and enzyme, etc. Nanocarriers could respond to stimuli in tumor microenvironments or inside cancer cells for on-demanded drug delivery and accumulation, controlled drug release, activation of bioactive compounds, probes and targeting ligands, as well as size, charge and conformation conversion, etc., leading to sensing and signaling, overcoming multidrug resistance, accurate diagnosis and precision therapy. This review has summarized the general strategies of developing stimuli-responsive nanocarriers and recent advances, presented their applications in drug delivery, tumor imaging, therapy and theranostics, illustrated the progress of clinical translation and made prospects.

Subfields: Biomaterials, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/bc9907fe2b45335fd1e928bdd460561a7e57b416

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In Biomedical Engineering

1. Xiaoyuan Chen
2. T. Lammers

Citations in the corpus

• The EPR effect and beyond: Strategies to improve tumor targeting and cancer nanomedicine treatment efficacy (2020, background): “Mi summarizes nanomedicines with stimuli responsiveness for tumor targeted imaging, therapy and theranostics [34].”