Strategies for advancing cancer nanomedicine

By Vikash P Chauhan, Rakesh K. Jain. Nature Materials, 2013

754 citations recorded by the source corpus.

Cancer nanomedicines approved so far minimize toxicity, but their efficacy is often limited by physiological barriers posed by the tumour microenvironment. Here, we discuss how these barriers can be overcome through innovative nanomedicine design and through creative manipulation of the tumour microenvironment.

Subfields: Biomaterials, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/bc715591073d1dd7a9b2cc601d3309a34526d6ee

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4. Nathan D. Donahue

In Biomedical Engineering

1. Shuming Nie

Citations in the corpus

• Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy (2016, background): “To adequately address these barriers and achieve effective therapy, nanoparticles must be rationally designed to overcome substantial interstitial transport hindrance brought about by their inherently large sizes to realize deep and uniform tumor penetration (7).”
• Insight into nanoparticle cellular uptake and intracellular targeting (2014, neutral): “The drug loaded nanoparticles have to overcome a number of transport barriers to reach the specific cells [23].”
• Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine. (2019, background): “healthy and diseased cells through the use of precise biomolecular recognition strategies [26,27].”