Vitamin D Receptor As an Intestinal Bile Acid Sensor

By M. Makishima, T. T. Lu, W. Xie, G. Whitfield, H. Domoto, R. Evans, M. Haussler, D. Mangelsdorf. Science, 2002

1,145 citations recorded by the source corpus.

Subfields: Oncology, Pathology and Forensic Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/bbe7b6a5e5f8133a2801c57219ef498ff45f233e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. Christoph Borner
2. D. Mangelsdorf
3. P. Tontonoz
4. J. Y. Chiang

In Surgery

1. A. Ramachandran
2. H. Jaeschke
3. D. Mangelsdorf
4. P. Tontonoz

Citations in the corpus

• Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. (2006, background): “VDR also functions as a sensor of toxic bile acids in the colon (Makishima et al., 2002) and may protect against colorectal cancer (Kallay et al., 2001).”
• Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME (2013, positive): “VDR is also transactivated by the highly hydrophobic and toxic secondary bile acid, lithocholic acid (Makishima et al. 2002).”