Flexible, Foldable, Actively Multiplexed, High-Density Electrode Array for Mapping Brain Activity in vivo

By J. Viventi, Dae-Hyeong Kim, L. Vigeland, E. Frechette, Justin A. Blanco, Yun-Soung Kim, Andrew E. Avrin, V. Tiruvadi, Suk-Won Hwang, Ann C. Vanleer and 11 more. Nature Neuroscience, 2011

1,120 citations recorded by the source corpus.

Arrays of electrodes for recording and stimulating the brain are used throughout clinical medicine and basic neuroscience research, yet are unable to sample large areas of the brain while maintaining high spatial resolution because of the need to individually wire each passive sensor at the electrode-tissue interface. To overcome this constraint, we developed new devices that integrate ultrathin and flexible silicon nanomembrane transistors into the electrode array, enabling new dense arrays of thousands of amplified and multiplexed sensors that are connected using fewer wires. We used this system to record spatial properties of cat brain activity in vivo, including sleep spindles, single-trial visual evoked responses and electrographic seizures. We found that seizures may manifest as recurrent spiral waves that propagate in the neocortex. The developments reported here herald a new generation of diagnostic and therapeutic brain-machine interface devices.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/bbd162eb8f4aaccb5db074efe5f0e6eb421af799

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Automated long-term recording and analysis of neural activity in behaving animals (2016, background): “…technology to increase the number of neurons that can be simultaneously recorded from (Berényi et al., 2014; Buzsáki et al., 2015; Du et al., 2011; Viventi et al., 2011), as well as make the recordings more stable (Alivisatos et al., 2013; Chestek et al., 2011; Cogan, 2008; Felix et al., 2013;…”
A Minimally Invasive 64-Channel Wireless μECoG Implant (2015, background): “In the last decade, high-density micron-scale ECoG ( ECoG) grids have gained increased traction among neurosurgeons for more precise mapping of seizure onset zones, eloquent cortex, and for clinical research [7], [8].”
Flexible electronics under strain: a review of mechanical characterization and durability enhancement strategies (2016, background): “Within the body, flexible electronic devices are also being investigated as neural interfaces for mapping brain activity [109, 127], restoring motor function by stimulating spinal neurons [109, 128] or restoring vision in the eye [129].”
Inorganic semiconducting materials for flexible and stretchable electronics (2017, result): “These examples illustrate excellent spatio-temporally resolved spiking activity, comparable to the best results possible with non-resorbable technologies (right, right column).(10) These and other opportunities for bioresorbable electronic devices foreshadow even higher levels of sophistication and ”