Chromatin modifiers: regulators of cellular differentiation
By Taiping Chen, Sharon Y. R. Dent. Nature reviews genetics, 2013
619 citations recorded by the source corpus.
Cellular differentiation is, by definition, epigenetic. Genome-wide profiling of pluripotent cells and differentiated cells suggests global chromatin remodelling during differentiation, which results in a progressive transition from a fairly open chromatin configuration to a more compact state. Genetic studies in mouse models show major roles for a variety of histone modifiers and chromatin remodellers in key developmental transitions, such as the segregation of embryonic and extra-embryonic lineages in blastocyst stage embryos, the formation of the three germ layers during gastrulation and the differentiation of adult stem cells. Furthermore, rather than merely stabilizing the gene expression changes that are driven by developmental transcription factors, there is emerging evidence that chromatin regulators have multifaceted roles in cell fate decisions.
Subfields: Molecular Biology
View Paper: https://www.semanticscholar.org/paper/bbb9d5d9b73d1fbba9e1cc509d4863d1632047d9
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Molecular Biology
- Jason D. Buenrostro
- W.J. Greenleaf
- Beijing Wu
- Howard Y. Chang
- Rahul Satija
- Pedro J. Batista
- Ling-Ling Chen
- M. Corces
Citations in the corpus
- ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide (2015, background): “…this epigenetic structure, providing information on transcription factor binding, the positions of modified and canonical nucleosomes, and chromatin accessibility at regulatory elements such as promoters, enhancers, and insulators (Valouev et al., 2011; Consortium, 2012; Thurman et al., 2012).”
- Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation (2017, neutral): “Recent genome-wide mapping studies have suggested that epigenetic pre-patterning is important for spatio-temporal regulation of gene expression and may be a widespread phenomenon in cell fate decision (Chen and Dent, 2014).”