Synaptic tagging and capture in the living rat

By K. L. Shires, B. M. D. Silva, J. P. Hawthorne, R. Morris, Stephen J. Martin. 2012

67 citations recorded by the source corpus.

In isolated hippocampal slices, decaying long-term potentiation can be stabilized and converted to late long-term potentiation lasting many hours, by prior or subsequent strong high-frequency tetanization of an independent input to a common population of neurons—a phenomenon known as ‘synaptic tagging and capture’. Here we show that the same phenomenon occurs in the intact rat. Late long-term potentiation can be induced in CA1 during the inhibition of protein synthesis if an independent input is strongly tetanized beforehand. Conversely, declining early long-term potentiation induced by weak tetanization can be converted into lasting late long-term potentiation by subsequent strong tetanization of a separate input. These findings indicate that synaptic tagging and capture is not limited to in vitro preparations; the past and future activity of neurons has a critical role in determining the persistence of synaptic changes in the living animal, thus providing a bridge between cellular studies of protein synthesis-dependent synaptic potentiation and behavioural studies of memory persistence. Synaptic tagging and capture describes thein vitro protein synthesis-dependent neuronal process where short-lasting forms of response potentiation are stabilised into long-lasting forms. Shires and colleagues find that this phenomenon also occurs in vivoin intact, living animals.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

Synaptic weight decay with selective consolidation enables fast learning without catastrophic forgetting (2019, methodology): “5B, Shires et al. (2012)).”