A review on phospholipids and their main applications in drug delivery systems
By J. Li, Xuling Wang, Tingting Zhang, Chunling Wang, Zhen-jun Huang, Xiang Luo, Yihui Deng. 2015
890 citations recorded by the source corpus.
Abstract Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity. These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of applications in drug delivery systems. The aim of this review is to summarize phospholipids and some of their related applications in drug delivery systems, and highlight the relationship between the properties and applications, and the effect of the species of phospholipids on the efficiency of drug delivery. We refer to some relevant literatures, starting from the structures, main sources and properties of phospholipids to introduce their applications in drug delivery systems. The present article focuses on introducing five types of carriers based on phospholipids, including liposomes, intravenous lipid emulsions, micelles, drug-phospholipids complexes and cochleates.
Subfields: Biomaterials, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/bba2b27f36b5942fbf4d33b2e369b34e9a59a8b7
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In Biomaterials
In Molecular Biology
Citations in the corpus
- The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “Phospholipids are also a main component of cellular membranes (Li et al., 2015).”
- A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives (2022, background): “In addition, the unsaturated fatty acid of EPC leads to a low phase transition temperature of −15~−5 ◦C [53], indicating the liposome bilayer is in a disorder and drug “leaky” state in the body temperature.”
- Topology Prediction of α-Helical Transmembrane Proteins (2016, background): “The most common group of lipids in the membrane is the phospholipids [16].”