Stem cell transplantation: the lung barrier.

By S. Schrepfer, T. Deuse, H. Reichenspurner, M. Fischbein, R. Robbins, M. Pelletier. Transplantation Proceedings, 2007

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Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect (2009, background): “Furthermore, treatment of the animals with sodium nitroprusside for vasodilation resulted in an increased pulmonary passage [11].”
Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis (2014, neutral): “However, only a small number of Gli1 cells engrafted into bone marrow (Figures 6D and 6E), whereas many more Gli1 cells were trapped in the lung (Figures 6C–6E), consistent with previous reports (Schrepfer et al., 2007).”
Intravenous hMSCs Improve Myocardial Infarction in Mice because Cells Embolized in Lung Are Activated to Secrete the Anti-inflammatory Protein TSG-6 (2009, background): “As expected (Gao et al., 2001; Schrepfer et al., 2007; Lee et al., 2009), most of the cells cleared from the circulation were trapped in the lung.”
Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, neutral): “shown that often, most of the systemically administered MSCs are entrapped within the lungs [83,84].”