Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): A randomised, placebo-controlled trial

By Ja Williams-Johnson, Ah Mcdonald, G. Strachan, E. Williams. Indian Journal of Neurotrauma, 2012

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The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition (2016, background): “The Clinical Randomisation of Antifibrinolytic therapy in Significant Haemorrhage (CRASH-2) trial [409] assessed the effects of early administration of a short course of TXA on death, vascular occlusive events and the receipt of blood product transfusion in trauma patients who were bleeding or at ri”
The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation. (2018, background): “Tranexamic acid has proven efficacy to support haemostasis, particularly in trauma-induced bleeding, with a favourable safety profile.(257,258) Even when not yet supported by clinical data its use can therefore be considered for bleeding under NOACs, especially in situations of severe bleeding where”
The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition (2019, background): “The Clinical Randomisation of Antifibrinolytic therapy in Significant Haemorrhage (CRASH-2) trial [488] assessed the effects of early administration of a short course of TXA on death, vascular occlusive events and the”
Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy (2017, background): “in acute trauma patients given tranexamic acid [133].”