X-Ray Structure of the hRORα LBD at 1.63 Å

By J. Kallen, J. Schlaeppi, F. Bitsch, S. Geisse, M. Geiser, Isabelle Delhon, B. Fournier. 2002

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Overview of Nomenclature of Nuclear Receptors (2006, background): “On the other hand, some lipophilic molecules have been proposed to serve a structural function in constitutively active NRs, with HNF-4 binding fatty acid and ROR (cid:1) binding cholesterol (Dhe-Paganon et al., 2002; Kallen et al., 2002; Wisely et al., 2002).”
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism (2009, background): “…that RORs do not form homodimers or heterodimers with other RORs or RXRs. RORs: ligand-dependent transcription factors Crystallography provided not only insights into the structure of the LBD, but also into size of the ligand binding pockets of RORs [Kallen et al., 2002; Stehlin et al., 2001].”