The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Overview
By D. Nathan. Diabetes Care, 2013
1,692 citations recorded by the source corpus.
OBJECTIVE The Diabetes Control and Complications Trial (DCCT) was designed to test the glucose hypothesis and determine whether the complications of type 1 diabetes (T1DM) could be prevented or delayed. The Epidemiology of Diabetes Interventions and Complications (EDIC) observational follow-up determined the durability of the DCCT effects on the more-advanced stages of diabetes complications including cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS The DCCT (1982–1993) was a controlled clinical trial in 1,441 subjects with T1DM comparing intensive therapy (INT), aimed at achieving levels of glycemia as close to the nondiabetic range as safely possible, with conventional therapy (CON), which aimed to maintain safe asymptomatic glucose control. INT utilized three or more daily insulin injections or insulin pump therapy guided by self-monitored glucose. EDIC (1994–present) is an observational study of the DCCT cohort. RESULTS The DCCT followed >99% of the cohort for a mean of 6.5 years and demonstrated a 35–76% reduction in the early stages of microvascular disease with INT, with a median HbA1c of 7%, compared with CONV, with a median HbA1c of 9%. The major adverse effect of INT was a threefold increased risk of hypoglycemia, which was not associated with a decline in cognitive function or quality of life. EDIC showed a durable effect of initial assigned therapies despite a loss of the glycemic separation (metabolic memory) and demonstrated that the reduction in early-stage complications during the DCCT translated into substantial reductions in severe complications and CVD. CONCLUSIONS DCCT/EDIC has demonstrated the effectiveness of INT in reducing the long-term complications of T1DM and improving the prospects for a healthy life span.
Subfields: Endocrinology, Diabetes and Metabolism, Genetics
View Paper: https://www.semanticscholar.org/paper/ba81fbee15d437392bec7fac5738a31f1709c225
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In Endocrinology, Diabetes and Metabolism
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Citations in the corpus
- The Potential Cost Implications of Averting Severe Hypoglycemic Events Requiring Hospitalization in High-Risk Adults With Type 1 Diabetes Using Real-Time Continuous Glucose Monitoring (2016, background): “Intensive therapy has become the standard of care for treatment of type 1 diabetes (T1DM) based on its proven ability to help patients achieve near-normal glucose levels and significantly reduce the risk of microvascular diabetes complications and cardiovascular disease events.(1) Unfortunately, int”
- Glucose Sensing for Diabetes Monitoring: Recent Developments (2017, background): “Recent developments in implantable sensors, on the other hand, can be used to incorporate insulin pumps, which allow for instant insulin administration [20,35,42,43,45].”
- Non-Invasive Blood Glucose Monitoring Technology: A Review (2020, background): “Therefore, many related fields have been actively devoted to the research of diabetes [3].”