Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.

By Di Chen, Q. Cui, Huanjie Yang, Q. Dou. Cancer Research, 2006

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Copper in diseases and treatments, and copper‐based anticancer strategies (2009, background): “Copper complexes bearing a thioxo group, such as disulfiram, showed strong toxicity against cancer cell lines or cancer xenografts.(195) Dallavalle et al.”
Copper metabolism in cell death and autophagy (2023, background): “Disulfiram is one of the clinical drugs approved to treat alcoholism [89].”
Copper induces cell death by targeting lipoylated TCA cycle proteins (2022, background): “Genetic variation in copper homeostasis results in life-threatening disease (39, 40), and both copper ionophores (11, 17, 41, 42) and copper chelators (43–46) have been suggested as anticancer agents.”
Copper complexes as anticancer agents. (2009, background): “Copper complexes bearing a thioxo group, such as disulfiram, showed strong toxicity against cancer cell lines or cancer xenografts [119,149].”