C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

By G. Hoeffel, Jinmiao Chen, Yonit Lavin, Donovan Low, Francisca F. Almeida, Peter See, Anna E. Beaudin, Josephine Lum, Ivy Low, E. Forsberg and 10 more. Immunity, 2015

1,001 citations recorded by the source corpus.

Summary Although classified as hematopoietic cells, tissue- resident macrophages (MFs) arise from embryonic precursors that seed the tissues prior to birth to generate a self-renewing population, which is maintained independently of adult hematopoiesis. Here we reveal the identity of these embryonic precursors using an in utero MF-depletion strategy and fate-mapping of yolk sac (YS) and fetal liver (FL) hematopoiesis. We show that YS MFs are the main precursors of microglia, while most other MFs derive from fetal monocytes (MOs). Both YS MFs and fetal MOs arise from erythro-myeloid progenitors (EMPs) generated in the YS. In the YS, EMPs gave rise to MFs without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal MOs that then seeded embryonic tissues and differentiated into MFs. Thus, adult tissue- resident MFs established from hematopoietic stem cell-independent embryonic precursors arise from two distinct developmental programs.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/b9ff5a776d8532691a3395efa7b039004495929c

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In Immunology

Citations in the corpus

Specification of tissue-resident macrophages during organogenesis (2016, result): “For example, the progressive YFP expression by fetal macrophages in S100a4; Rosa26 mice (12) is compatible with our present findings and does not require the existence of a second wave of precursors because expression of S100a4 and several other S100a family members was found to be part of the pMac ”
Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain (2017, background): “, 2013), although the contribution of monocytes has not been observed in fate mapping studies (Hoeffel et al., 2015; Sheng et al., 2015).”
Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches (2019, methodology): “In adult S100a4-Rosa mice, all bone marrow (BM) hematopoietic cells, including monocytes, are 100%enhanced yellow fluorescent protein (EYFP)– labeled (4).”